Fasting glucose / type 2 diabetes (MTNR1B)

MTNR1B · Health · Evidence ★★★★☆

MTNR1B is a melatonin receptor on the insulin-producing cells of the pancreas. A common variant raises fasting blood sugar slightly and modestly increases type 2 diabetes risk, partly by tying melatonin and sleep timing to insulin release.

Possible results

Typical fasting glucose (MTNR1B). You don't carry the MTNR1B blood-sugar variant, so as far as this gene goes, your fasting glucose and type 2 diabetes risk sit at the baseline. Weight, diet and activity still matter most.

Slightly higher fasting glucose. You carry one copy of the MTNR1B variant linked to slightly higher fasting blood sugar and a modest increase in type 2 diabetes risk. The effect is small and very manageable with the usual diet, activity and weight habits.

Higher fasting glucose. You have two copies of the MTNR1B variant tied to higher fasting blood sugar and a modestly raised type 2 diabetes risk. It's a tendency, not a diagnosis: lifestyle is the main lever, and a simple fasting-glucose or HbA1c blood test shows your actual level.

Evidence & sources

This variant appears in 25 published genetic studies: PubMed 22885922 · PubMed 24509480 · PubMed 28254843 · PubMed 28869590 · PubMed 29743933 · PubMed 30054458 · PubMed 30297969 · PubMed 30595370 · PubMed 31021400 · PubMed 32499647 · PubMed 32541925 · PubMed 33402679 · PubMed 34059833 · PubMed 34610981 · PubMed 34951656 · PubMed 35551307 · PubMed 35902682 · PubMed 36329257 · PubMed 36738649 · PubMed 38116116 · PubMed 38374256 · PubMed 38685053 · PubMed 39024449 · PubMed 39379762 · PubMed 40210677.

References: dbSNP · GWAS Catalog · PubMed · SNPedia

Educational and informational only, not medical advice.

How we interpret results · How to read your raw DNA data

Already have your 23andMe, AncestryDNA, or FamilyTreeDNA file?

See your own result.

Fasting glucose / type 2 diabetes (MTNR1B)

Possible results

Evidence & sources

Related