Crohn's disease susceptibility

The NOD2 gene helps the gut immune system sense bacteria. A NOD2 variant modestly raises susceptibility to Crohn's disease, but most carriers never develop it.

Possible results

No Crohn's risk variant. You don't carry this NOD2 variant linked to Crohn's disease, so from what this gene shows your risk is at baseline. Crohn's is shaped by many genes and environmental factors together.

Slightly higher Crohn's risk. You carry one copy of a NOD2 variant that modestly raises susceptibility to Crohn's disease, an inflammatory bowel condition. Most people who carry it never develop Crohn's, since it's only one of several risk factors. It's a small nudge in risk, not a prediction.

Higher Crohn's risk. You have two copies of this NOD2 Crohn's variant, which raises susceptibility more than a single copy. Even so, most carriers stay healthy, because Crohn's depends on a mix of genes and environment. Worth being aware of if you have persistent gut symptoms.

Evidence & sources

Across global populations, fewer than 1% of people carry two copies of this variant, and about 93% carry none.

This variant appears in 2 published genetic studies: PubMed 28067908 · PubMed 41661118.

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